High Fluid Shear Stress and Spatial Shear Stress Gradients Affect Endothelial Proliferation, Survival, and Alignment
نویسندگان
چکیده
منابع مشابه
Fluid shear, intercellular stress, and endothelial cell alignment.
Endothelial cell alignment along the direction of laminar fluid flow is widely understood to be a defining morphological feature of vascular homeostasis. While the role of associated signaling and structural events have been well studied, associated intercellular stresses under laminar fluid shear have remained ill-defined and the role of these stresses in the alignment process has remained obs...
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In vitro investigations of the responses of vascular endothelium to fluid shear stress have typically been conducted under conditions where the time-mean shear stress is uniform. In contrast, the in vitro experiments reported here have re-created the large gradients in surface fluid shear stress found near arterial branches in vivo; specifically, we have produced a disturbed-flow region that in...
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ژورنال
عنوان ژورنال: Annals of Biomedical Engineering
سال: 2011
ISSN: 0090-6964,1573-9686
DOI: 10.1007/s10439-011-0267-8